NFL Players May Be at Higher Risk of Death from Alzheimer’s and ALS
MINNEAPOLIS – New 
research shows that professional football players may be at a higher 
risk of death from diseases that damage the cells in the brain, such as 
Alzheimer’s disease and ALS (also known as Lou Gehrig’s disease), 
compared to the general U.S. population. The study is published in the 
September 5, 2012, online issue of Neurology®, the medical journal of the American Academy of Neurology.
 
The study included 3,439 players with an average age of 57 from the 
National Football League with at least five playing seasons from 
1959-1988.  Researchers reviewed death certificates for causes of death 
from Alzheimer’s disease, Parkinson’s disease and ALS. At the time of 
the analysis, only 10 percent of the participants had passed away.
The research found that professional football players in this study were
 three times more likely to die as a result of diseases that damage 
brain cells compared to the general population. A player’s risk of death
 from Alzheimer’s disease or ALS was almost four times higher than the 
general population. Of the 334 who died, seven had Alzheimer’s disease 
and seven had ALS. The risk of dying from Parkinson’s disease was not 
significantly different than that of the general population.    
To determine if these risks differed by position played, researchers 
divided the players into two groups: those who played non-line (“speed”)
 positions which included quarterbacks, running backs, halfbacks, 
fullbacks, wide receivers, tight ends, defensive backs, safeties and 
linebackers, and those who played line (“non-speed”) positions, which 
included defensive and offensive linemen. Speed position players were 
more than three times more likely to die from a neurodegenerative cause 
than non-speed position players. A total of 62 percent of the players 
were in speed positions.   
“These results are consistent with recent studies that suggest an 
increased risk of neurodegenerative disease among football players,” 
said study author Everett J. Lehman, MS, with the National Institute for
 Occupational Safety and Health in Cincinnati. “Although our study 
looked at causes of death from Alzheimer’s disease and ALS as shown on 
death certificates, research now suggests that chronic traumatic 
encephalopathy (CTE) may have been the true primary or secondary factor 
in some of these deaths. A brain autopsy is necessary to diagnose CTE 
and distinguish it from Alzheimer's or ALS. While CTE is a separate 
diagnosis, the symptoms are often similar to those found in Alzheimer’s,
 Parkinson’s and ALS, and can occur as the result of multiple 
concussions.” 
Lehman said the study was limited by the small number of deaths in the 
analysis.
The study was supported by the National Institute for Occupational 
Safety and Health.
To learn more about CTE, Alzheimer’s disease, ALS and Parkinson’s 
disease, visit http://www.aan.com/patients.
The American Academy of Neurology, an association of 
more than 25,000 neurologists and neuroscience professionals, is 
dedicated to promoting the highest quality patient-centered neurologic 
care. A neurologist is a doctor with specialized training in diagnosing,
 treating and managing disorders of the brain and nervous system such as
 Alzheimer’s disease, stroke, migraine, multiple sclerosis, brain 
injury, Parkinson’s disease and epilepsy. 
For more information about the American Academy of Neurology, visit http://www.aan.com or find us on Facebook, Twitter, Google+ and YouTube.
             
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