Ann Intern Med. 1981 Apr;94(4 pt 1):475-77.
Granulomatous hepatitis due to Candida albicans in patients with acute leukemia.
Abstract
Deep-seated
candidiasis developed after chemotherapy in two patients with acute
leukemia. The patients developed granulomatous hepatitis caused by
Candida albicans but had no evidence of disseminated candidiasis.
Candida could not be isolated from liver biopsies taken from these
patients, but yeast and filamentous fungal forms could be identified
histochemically within the granulomas found in the biopsy specimens.
Quantitation of anticandida antibody levels confirmed that deep-seated
candida infection had occurred in both patients. The gastrointestinal
tract was the only reasonable portal of entry for Candida in both
patients. A diagnosis of candida-induced granulomatous hepatitis should
be considered if high, unexplained fever and strikingly elevated serum
alkaline phosphatase levels develop in a patient with acute leukemia
after an intensive course of chemotherapy.
- PMID:
- 7011139
- [PubMed - indexed for MEDLINE]
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