An opportunistic infection is an infection caused by bacterial, viral, fungal, or protozoan pathogens that take advantage of a host with a weakened immune system. Many of these pathogens do not cause disease in a healthy host that has a normal immune system. A compromised immune system, however, presents an "opportunity" for the pathogen to infect.
Since opportunistic infections can cause severe disease, much emphasis is placed on measures to prevent infection. Such a strategy usually includes restoration of the immune system as soon as possible, avoiding exposures to infectious agents, and using antimicrobial medications ("prophylactic medications") directed against specific infections.
In patients with HIV, starting antiretroviral therapy is especially important for restoration of the immune system and reduces the incidence of all opportunistic infections[5][6]
In patients undergoing chemotherapy, completion of and recovery from treatment is the primary method for immune system restoration. In a select subset of high risk patients, granulocyte colony stimulating factors (G-CSF) can be used to aid immune system recovery.[7][8]
Unprotected sexual intercourse with individuals with known sexually transmitted infections. Any sex practice that might result in oral exposure to feces.
Individuals at higher risk are often prescribed prophylactic medication to prevent an infection from occurring. A patient's risk level for developing an opportunistic infection is approximated using the patient's CD4 T-cell count and sometimes other markers of susceptibility. Common prophylaxis treatments include the following:[10]
Jump up ^Knoester, M.; Lashley, L. E. E. L. O.; Wessels, E.; Oepkes, D.; Kuijper, E. J. (2011). "First Report of Atopobium vaginae Bacteremia with Fetal Loss after Chorionic Villus Sampling". Journal of Clinical Microbiology49 (4): 1684–1686. doi:10.1128/JCM.01655-10. ISSN0095-1137.
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