Monday, 22 September 2014

I was looking for Candida and Epstein Barr Virus and Came across Professor Mark Vickers Aberdeen School of Medicine

Professor Mark Vickers

Professor Mark Vickers The University of Aberdeen School of Medicine & Dentistry Chair in Applied Medicine (Clin) work +44 (0)1224 512401 work fax 554761 pref
Chair in Applied Medicine (Clin)
MBChB MRCP DM FRCPath

Contact Details

Telephone: +44 (0)1224 512401
Fax: 554761
Email:m.a.vickers@abdn.ac.uk
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Biography

Mark Vickers graduated from Oxford University in 1983, having completed his preclinical studies at Cambridge with a Biochemistry Part II. After general medical jobs in London, Dr Vickers took up an MRC Training Fellowship at the Institute of Molecular Medicine in Oxford, working with Doug Higgs on genes surrounding the alpha-globin gene cluster. He then trained in Haematology at the Hammersmith, Reading and John Radcliffe Hospitals from (1990–1996). He took up his current post as Senior Lecturer at Aberdeen in 1996 and was promoted to Professor in the section of Applied Medicine in 2008. He took up directorship of the Academic Transfusion Medicine Unit in 2010.

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Research Interests

Mark Vickers' main interests are cellular immune responses to Epstein-Barr virus (EBV) and how red blood cells die.  EBV can cause infectious mononucleosis (IM), some lymphomas and possibly certain autoimmune diseases.  Work on EBV encompasses the epidemiology of IM, meta-analyses of the associations between viral infection and immune mediated diseases and laboratory analyses of CD4 responses to the virus.  In addition, he is involved in a Wellcome Trust funded anti-EBV cytotoxic lymphocyte bank used to treat EBV driven lymphomas based in Aberdeen.  The molecular basis for how red cells are taken up by macrophages is not only important as a model system for how cells signal their health and age to the outside world and determine the nature of macrophage responses but also may be important in determining side effects of blood transfusion.
He also continues to work on the aetiology of Hodgkin lymphoma, the impact of UV light on the immune system and modelling human haematopoietic stem cells in vivo.

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Teaching Responsibilities

Dr Vickers has been an enthusiastic bedside teacher for many years and co-ordinated the third year medical degree until 2010.

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Publications

Contributions to Journals

Articles

  • Hall, LS., Hall, AM., Pickford, W., Vickers, MA., Urbaniak, SJ. & Barker, RN. (2014). 'Combination peptide immunotherapy suppresses antibody and helper T cell responses to the RhD protein in HLA-transgenic mice'. Haematologica, vol 99, no. 3, pp. 588-596.
    [Online] DOI: 10.3324/haematol.2012.082081
  • Whibley, N., Maccallum, DM., Vickers, MA., Zafreen, S., Waldmann, H., Hori, S., Gaffen, SL., Gow, NAR., Barker, RN. & Hall, AM. (2014). 'Expansion of Foxp3+ T-cell populations by Candida albicans enhances both Th17-cell responses and fungal dissemination after intravenous challenge'. European Journal of Immunology, vol 44, no. 4, pp. 1069-1083.
    [Online] DOI: 10.1002/eji.201343604
    [Online] AURA: EJI_whibley.pdf
  • Visser, E., Milne, D., Collacott, I., McLernon, D., Counsell, C. & Vickers, M. (2014). 'The epidemiology of infectious mononucleosis in Northern Scotland: a decreasing incidence and winter peak'. BMC Infectious Diseases, vol 14, 151.
    [Online] DOI: 10.1186/1471-2334-14-151
    [Online] AURA: Epidemiol_of_IM_in_Grampian.pdf
  • Hanlon, P., Avenell, A., Aucott, L. & Vickers, MA. (2014). 'Systematic review and meta-analysis of the sero-epidemiological association between Epstein-Barr virus and systemic lupus erythematosus'. Arthritis Research & Therapy, vol 16, no. 1, R3.
    [Online] DOI: 10.1186/ar4429
  • Forrester, MA., Robertson, L., Bayoumi, N., Keavney, BD., Barker, RN. & Vickers, MA. (2014). 'Human interleukin-27: wide individual variation in plasma levels and complex inter-relationships with interleukin-17A'. Clinical and Experimental Immunology.
    [Online] DOI: 10.1111/cei.12408
  • Ward, FJ., Dahal, LN., Wijisekera, SK., Abdul-Jawad, SK., Kaewarpai, T., Xu, H., Vickers, MA. & Barker, RN. (2013). 'The soluble isoform of CTLA-4 as a regulator of T-cell responses'. European Journal of Immunology, vol 43, no. 5, pp. 1274-1285.
    [Online] DOI: 10.1002/eji.201242529
  • Almohmeed, YH., Avenell, A., Aucott, L. & Vickers, MA. (2013). 'Systematic review and meta-analysis of the sero-epidemiological association between Epstein Barr virus and multiple sclerosis'. PLoS ONE, vol 8, no. 4, e61110.
    [Online] DOI: 10.1371/journal.pone.0061110
  • Milliken, SVI., Wassall, H., Lewis, BJ., Logie, J., Barker, RN., Macdonald, H., Vickers, MA. & Ormerod, AD. (2012). 'Effects of ultraviolet light on human serum 25-hydroxyvitamin D and systemic immune function'. Journal of Allergy and Clinical Immunology, vol 129, no. 6, pp. 1554-1561.
    [Online] DOI: 10.1016/j.jaci.2012.03.001
  • Stephen, J., Cairns, LS., Pickford, WJ., Vickers, MA., Urbaniak, SJ. & Barker, RN. (2012). 'Identification, immunomodulatory activity, and immunogenicity of the major helper T-cell epitope on the K blood group antigen'. Blood, vol 119, no. 23, pp. 5563-5574.
    [Online] DOI: 10.1182/blood-2012-02-410324
  • Hall, AM., Zamzami, OM., Whibley, N., Hampsey, DP., Haggart, AM., Vickers, MA. & Barker, RN. (2012). 'Production of the effector cytokine interleukin-17, rather than interferon-γ, is more strongly associated with autoimmune hemolytic anemia'. Haematologica, vol 97, no. 10, pp. 1494-1500.
    [Online] DOI: 10.3324/haematol.2011.060822
  • Lawrie, A., Stevenson, DAJ., Doig, T., Vickers, MA. & Culligan, DJ. (2012). 'Acute myeloid leukemia presenting in a mother and daughter pair with the identical acquired karyotypic abnormality consisting of inversion 3q21q26 and monosomy 7: a review of possible mechanisms'. Cancer Genetics and Cytogenetics, vol 205, no. 11, pp. 599-602.
    [Online] DOI: 10.1016/j.cancergen.2012.09.001
  • Crowther, M., Chan, YLT., Garbett, IK., Lim, W., Vickers, MA. & Crowther, MA. (2011). 'Evidence-based focused review of the treatment of idiopathic warm immune hemolytic anemia in adults'. Blood, vol 118, no. 15, pp. 4036-4040.
    [Online] DOI: 10.1182/blood-2011-05-347708
  • Hall, AM., Vickers, MA., Barker, RN. & Erwig, LP. (2009). 'Helper T cells point the way to specific immunotherapy for autoimmune disease'. Cardiovascular & Hematological Disorders - Drug Targets, vol 9, no. 3, pp. 159-166.
    [Online] DOI: 10.2174/187152909789007043
  • Vickers, MA., Cunnington, MS., Mayosi, BM., Hall, DH., Avery, PJ., Farrall, M., Watkins, H. & Keavney, B. (2009). 'Genetic variants linked to coronary artery disease are not associated with carotid artery intima-media thickness or intermediate risk phenotypes'. Atherosclerosis, vol 203, no. 1, pp. 41-44.
    [Online] DOI: 10.1016/j.atherosclerosis.2008.06.025
  • Mittal, S., Marshall, NA., Duncan, L., Culligan, DJ., Barker, RN. & Vickers, MA. (2008). 'Local and systemic induction of CD4 + CD25 + regulatory T-cell population by non-Hodgkin lymphoma'. Blood, vol 111, no. 11, pp. 5359-5370.
    [Online] DOI: 10.1182/blood-2007-08-105395
  • Ward, FJ., Hall, AM., Cairns, LS., Leggat, AS., Urbaniak, SJ., Vickers, MA. & Barker, RN. (2008). 'Clonal regulatory T cells specific for a red blood cell autoantigen in human autoimmune hemolytic anemia'. Blood, vol 111, no. 2, pp. 680-687.
    [Online] DOI: 10.1182/blood-2007-07-101345
  • Mittal, S., Blaylock, MG., Culligan, DJ., Barker, RN. & Vickers, MA. (2008). 'A high rate of CLL phenotype lymphocytes in autoimmune haemolytic anaemia and immune thrombocytopenic purpura'. Haematologica, vol 93, no. 1, pp. 151-152.
    [Online] DOI: 10.3324/haematol.11822
  • Barker, RN., Vickers, MA. & Ward, FJ. (2007). 'Controlling autoimmunity—Lessons from the study of red blood cells as model antigens'. Immunology Letters, vol 108, no. 1, pp. 20-26.
    [Online] DOI: 10.1016/j.imlet.2006.10.005
  • Marshall, NA., Culligan, DJ., Tighe, J., Johnston, PW., Barker, RN. & Vickers, MA. (2007). 'The relationships between Epstein-Barr virus latent membrane protein 1 and regulatory T cells in Hodgkin's lymphoma'. Experimental Hematology, vol 35, no. 4, pp. 596-604.
    [Online] DOI: 10.1016/J.EXPHEM.2007.01.030
  • Vickers, MA. (2007). 'JAK2 V617F-positive polycythemia rubra vera maintained by approximately 18 stochastic stem cell divisions/year, explaining age of onest by a single rate-limiting mutation'. Blood, vol 110, no. 5, pp. 1675-1680.
    [Online] DOI: 10.1182/BLOOD-2006-12-061911
  • Marshall, NA., Culligan, DJ., Johnston, PW., Millar, C., Barker, RN. & Vickers, MA. (2007). 'CD4(+) T-cell responses to Epstein-Barr virus (EBV) latent membrane protein 1 in infectious mononucleosis and EBV-associated non-Hodgkin lymphoma: Th1 in active disease but Tr1 in remission'. British Journal of Haematology, vol 139, no. 1, pp. 81-89.
    [Online] DOI: 10.1111/j.1365-2141.2007.06765.x
  • Vickers, MA., Canning, SJ., Craig, WL., Masson, NM. & Wilson, IJ. (2006). 'X inactivation patterns of closely, but not distantly, related cells are highly correlated: little evidence for stem cell plasticity in normal females'. Stem Cells, vol 24, no. 11, pp. 2398-2405.
    [Online] DOI: 10.1634/stemcells.2006-0043
  • Gilmour, PS., Morrison, ER., Henriksen, P., Vickers, MA., Ford, I., Greaves, M., Donaldson, K. & MacNee, W. (2005). 'Pro-coagulant effects of environmental particles (PM10)'. Occupational and Environmental Medicine, vol 62, pp. 164-171.
    [Online] DOI: 10.1136/oem.2004.014951
  • Mittal, S., Milner, BJ. & Vickers, MA. (2005). 'Pyoderma gangrenosum as a cause of splenomegaly and association with a T-cell clone'. Clinical and Laboratory Haematology, vol 27, pp. 402-404.
    [Online] DOI: 10.1111/j.1365-2257.2005.00730.x
  • Hall, AM., Vickers, MA., McLeod, E. & Barker, RN. (2005). 'Rh autoantigen presentation to helper T cells in chronic lymphocytic leukemia by malignant B cells'. Blood, vol 105, no. 5, pp. 2007-2015.
    [Online] DOI: 10.1182/blood-2003-10-3563
  • Gilmour, PS., Ziesenis, A., Morrison, ER., Vickers, MA., Drost, EM., Ford, I., Karg, E., Mossa, C., Schroeppel, A., Ferron, GA., Heyder, J., Greaves, M., MacNee, W. & Donaldson, K. (2004). 'Pulmonary and systemic effects of short-term inhalation exposure to ultrafine carbon black particles'. Toxicology and Applied Pharmacology, vol 195, pp. 35-44.
    [Online] DOI: 10.1016/j.taap.2003.10.003
  • Marshall, NA., Christie, LE., Munro, LR., Culligan, DJ., Johnston, PW., Barker, RN. & Vickers, MA. (2004). 'Immunosuppressive regulatory T cells are abundant in the reactive lymphocytes of Hodgkin lymphoma'. Blood, vol 103, no. 5, pp. 1755-1762.
    [Online] DOI: 10.1182/blood-2003-07-2594
  • Munro, LR., Johnston, PW., Canning, SJ., Vickers, MA., Marshall, NA., Hewitt, SG. & Tveita, K. (2003). 'Polymorphisms in the interleukin-10 and interferon gamma genes in Hodgkin lymphoma'. Leukemia & Lymphoma, vol 44, no. 12, pp. 2083-2088.
    [Online] DOI: 10.1080/1042819031000119316
  • Vickers, MA., Ford, I., Morrison, R., Prescott, GJ., Watson, S., Hannaford, PC., Smith, WCS., Campbell, DM. & Greaves, M. (2003). 'Markers of endothelial activation and atherothrombosis in women with history of pre-eclampsia or gestational hypertension'. Thrombosis and Haemostasis, vol 90, no. 6, pp. 1192-1197.
    [Online] DOI: 10.1160/TH03-01-0053
  • Craig, WL., McKinlay, A. & Vickers, MA. (2003). 'Cellular turnover of normal gastrointestinal epithelium assessed by changes in telomeric: total DNA signal ratios'. European Journal of Gastroenterology & Hepatology, vol 15, no. 11, pp. 1195-1201.
    [Online] DOI: 10.1097/00042737-200311000-00008
  • Marshall, NA., Vickers, MA. & Barker, RN. (2003). 'Regulatory T cells secreting IL- 1 0 dominate the immune response to EBV latent membrane protein 1 1'. The Journal of Immunology, vol 170, no. 12, pp. 6183-6189.
  • Morrison, ER., Miedzybrodzka, ZH., Campbell, DM., Haites, NE., Wilson, B., Watson, M., Greaves, M. & Vickers, MA. (2002). 'Prothrombotic genotypes are not associated with pre-eclampsia and gestational hypertension: results from a large population-based study and systematic review'. Thrombosis and Haemostasis, vol 87, no. 5, pp. 779-785.
  • Vickers, MA., Green, FR., Mayosi, BM., Lathrop, M., Ratcliffe, PJ., Watkins, HC., Keavney, B., Terry, C. & Julier, C. (2002). 'Genotype at a promoter polymorphism of the interleukin-6 gene is associated with baseline levels of plasma C-reactive protein'. Cardiovascular Research, vol 53, no. 4, pp. 1029-1034.
    [Online] DOI: 10.1016/S0008-6363(01)00534-X
  • Vickers, MA., Hoy, T., Kyoizumi, S., Hewitt, M., Lake, H. & Boyse, J. (2002). 'Estimation of mutation rate at human glycophorin A locus in hematopoietic stem cell progenitors'. Environmental and Molecular Mutagenesis, vol 39, no. 4, pp. 333-341.
    [Online] DOI: 10.1002/em.10076
  • Hall, AM., Ward, FJ., Vickers, MA., Stott, L-M, Urbaniak, S. & Barker, RN. (2002). 'Interleukin-10-mediated regulatory T-cell responses to epitopes on a human red blood cell autoantigen'. Blood, vol 100, no. 13, pp. 4529-4536.
    [Online] DOI: 10.1182/blood-2002-05-1383
  • Meiklejohn, DJ., Vickers, MA., Morrison, ER., Dijkhuisen, R., Moore, I., Urbaniak, S. & Greaves, M. (2001). 'In vivo platelet activation in atherothrombotic stroke is not determined by polymorphisms of human platelet glycoprotein IIIa or Ib'. British Journal of Haematology, vol 112, no. 3, pp. 621-631.
    [Online] DOI: 10.1046/j.1365-2141.2001.02620.x
  • Horsley, SW., Daniels, RJ., Anguita, E., Raynham, HA., Peden, JF., Villegas, A. & Vickers, MA. (2001). 'Monosomy for the most telomeric, gene-rich region of human chromosome 16p causes minimal phenotypic effects'. EJHG : European journal of human genetics : the official journal of the European Society of Human Genetics., vol 9, pp. 217-225.
    [Online] DOI: 10.1038/sj.ejhg.5200610
  • Meiklejohn, DJ., Vickers, MA., Dijkhuisen, R. & Greaves, M. (2001). 'Plasma homocysteine concentrations in the acute and convalescent periods of atherothrombotic stroke'. Stroke, vol 32, no. 1, pp. 57-62.
  • Vickers, MA., McLeod, E., Wilson, IJ. & Spector, TD. (2001). 'Assessment of mechanism of acquired skewed X inactivation by analysis of twins'. Blood, vol 97, no. 5, pp. 1274-1281.
    [Online] DOI: 10.1182/blood.V97.5.1274
  • Mayosi, BM., Vickers, MA., Green, FR., Ratcliffe, PJ., Julier, C., Lathrop, GM., Watkins, H. & Keavney, B. (2001). 'Evidence for a quantitative trait locus for plasma fibrinogen from a family-based association study'. Genescreen, vol 1, pp. 151-155.
    [Online] DOI: 10.1046/j.1466-920x.2001.00037.x
  • Milner, BJ., Vickers, MA., Schofield, AC., Culligan, DJ., Tighe, JE., Haites, NE. & King, D. (2000). 'Beta-tubulin gene mutations and response to vinca alkaloids in acute lymphoblastic leukaemia'. Journal of Medical Genetics, vol 37, no. Supplement, pp. S42.

Letters

  • Crowther, M., Vickers, MA. & Avenell, A. (2009). 'A case of apples and pears?'. Blood, vol 113, no. 24, pp. 6259-6260.
    [Online] DOI: 10.1182/blood-2009-03-211169

Comments and Debates

  • Vickers, M. (2009). 'The doctor's dilemma: stimulating T cells'. Blood, vol 114, no. 16, pp. 3361-3362.
    [Online] DOI: 10.1182/blood-2009-08-236778

Scientific Reviews

  • Wu, O., Bayoumi, N., Vickers, MA. & Clark, P. (2008). 'ABO(H) blood groups and vascular disease: a systematic review and meta-analysis'. Journal of Thrombosis and Haemostasis, vol 6, no. 1, pp. 62-69.
    [Online] DOI: 10.1111/j.1538-7836.2007.02818.x

Editorials

  • Vickers, MA. & Greaves, M. (2005). 'The cryptic path from epitope to clot: a story of two domains?'. Blood, vol 105, pp. 1371-1372.
    [Online] DOI: 10.1182/blood-2004-11-4556

Abstracts

  • Whibley, NW., MacCallum, DM., Vickers, MA., Waldmann, H., Hori, S., Gow, NAR., Barker, RN. & Hall, AM. (2012). 'Candida albicans evades protective immunity by promoting the expansion of induced CD4(+) CD25(+) FoxP3(+) Helioslo regulatory T cells that enhance Th17 responses'. Immunology, vol 137, no. s1, pp. 206-206.
    [Online] DOI: 10.1111/imm.12002
  • Whibley, N., MacCallum, DM., Vickers, MA., Gow, NA., Barker, RN. & Hall, AM. (2011). 'Candida albicans promotes the differentiation of induced CD4(+) CD25(+) Foxp3(+) regulatory T cells'. Immunology, vol 135, no. Suppl. 1, pp. 161.
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