Persistence of Candida species in the respiratory tract of cystic fibrosis patients
February 2010, Vol. 48, No. 1 , Pages 56-63
Michaela Muthig, Alexandra Hebestreit, Uwe Ziegler, Marc Seidler, and Frank-Michael C. Müller
Department of Pediatrics, University Würzburg Josef-Schneider-Strasse 1, D-97080 Würzburg, Germany
Missionsärztliche Klinik GmbH, Salvatorstrasse 7, D-97067 Würzburg, Germany
Pediatric Pulmonology, Cystic Fibrosis Centre & Infectious Diseases, Department of Pediatrics III, University Heidelberg, Im Neuenheimer Feld 430, D-69120 Heidelberg, Germany
It is still controversial as to whether Candida spp. are transient or persistent colonizers of the respiratory tract of cystic fibrosis (CF) patients. We conducted a prospective study of 56 CF patients over a 30 month period to assess the distribution and persistence of different Candida spp. In vitro antifungal susceptibility testing was performed and the C. albicans isolates were typed with CARE-2 hybridization and other Candida spp. by RAPD-PCR for persistence and transmission. We found that the mean persistence of the most frequent Candida spp. was ≥ 9 months. In patients from whom more than 10 isolates were recovered, we noted that at least 30% were genetically related and transmission of C. albicans in siblings was observed. The majority of all isolates were susceptible to all antifungals tested. We concluded that there was long-term persistence of Candida in the respiratory tract of CF patients and that transmission between siblings may be one possible means of acquisition. Whether long-term colonization with Candida strains can contribute to the chronic infection and inflammation in the CF lung requires further investigation.
Read More: http://informahealthcare.com/doi/abs/10.3109/13693780802716532
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