Friday, 6 December 2013

Repost 2012 - UAE4EVA a year has past and they are still getting it wrong -

 my attention got diverted by other issues. but now my focus is back on. When i start to feel sorry for myself, I think of UAE4EVA and realize, that I have no right

 

For all UAE4EVAs out there

This young girl aged just 14 has been diagnosed with ms.this will be my last post for this year, because the most powerful post. on this blog

The life of this young girl and that of her parents were DESTROYED at one moment with one  little sentence "you have ms"  my son is 13 a year younger, just beginning his life as a teenager does, A NEW him, new ideas, new personality, NEW LIFE. what has been done to this girl is unforgivable, her life has been snuffed out, written off, by mistaken arrogant, men in suits, who have had the attitude that the only ALTERNATIVE is by finding a CURE. A cure for something that has been fabricated and made up over the years, with the help of gossip and assumption which has been able to grow under the nose of the MS SOCIETY an organization  which is supposed to help. RUBBISH!!!!!

I cant tell this young girl that they have got it WRONG, I cant tell her parents, as I dont know who they are either, and she is not now present on the new ms society boards, as she is under the age to be on them, and that is in a way a very good thing.

I know I am FIXABLE and am doing that, but she does not, her Christmas will be one of isolation and sadness. HOW DARE THEY!!! do this to her.

I will continue to FIGHT and be HEARD for all the UAE4EVAs out there, and that my friends is a lot of people.



What they have done and continue to do so in ignorance is  SHOCKING, and although I am feeling very good and happy, this truly BREAKS MY HEART to watch.

Thursday, 5 December 2013

The Atlas and other Neurological conditions

THE ANATOMY OF THE ATLAS SUBLUXATION

The atlas subluxation is so common yet so easily missed by mainstream medical practitioners. This problem is not very difficult to detect, in fact my daughter has become quite adept at picking out people walking down the street who exhibit the hallmarks of this upper cervical subluxation. There are maybe two reasons why most medical doctors do not detect this phenomenon. One could be that they doubt completely the existence of such subluxations and the other is maybe that their training is focussed on looking for major problems like dislocations, fractures, tumours and the like. The purpose of this section is to summarise what an atlas subluxation looks like and what actually happens to one's body when one does sustain such a misalignment of one's atlas. There is a wealth of information in medical texts, on websites and in scientific papers that provide more in-depth information. Hopefully, my summary will assist the layperson to understand the phenomenon, which is "the atlas subluxation".
The term 'subluxation' means 'minor misalignment' however the affects on the human body as a result of a subluxation of the first cervical vertebra (C1 or atlas) with respect to the skull can be far from 'minor'. To understand what the 'anatomy of an atlas subluxation' looks like it's first important to understand the anatomy of the atlas. The following graphic depicts the atlas (C1) vertebra articulating with the axis (C2) vertebra below it. The spinal cord with exiting spinal nerves can be seen tethered by dentate ligaments to the inner margins of the vertebral foramen. The human skull via the occipital condyles at the base of the skull sits on top of (or articulates with) the superior articular condylar surface of the atlas. According to Gray's Anatomy[1] "This articulation is a double condyloid joint. Its ligaments are the Anterior Occipito-atlantal, Posterior Occipito-atlantal, two Lateral Occipital-atlantal and two Capsular." There is a passage on each side in the Posterior Occipito-atlantal ligament to allow penetration of the vertebral arteries and 1st cervical nerves. The vertebral arteries exit the foramen in the atlas transverse processes; penetrate the ligament and then loop up into the brain. A number of strong ligaments support the skull and its contents and attach it to the cervical spine. Many other ligaments and muscles enable movement, bending, twisting and head rotation. There are other key structures within the vicinity of the atlas and supporting ligaments. These are 4 pairs of cranial nerves, namely the vagus, spinal accessory, glossopharyngeal and hypoglossal. The common carotid arteries, which run underneath the sternocleidomastoid muscle and jugular veins, are also present in the tissues of the neck. At the base of the neck near the junction of the shoulders there are some deep muscles known as the scalenes. These are the posterior, middle and anterior scalenes. The anterior scalenes are of particular interest as they are in very close proximity to the brachial plexus of nerves and the origin of the vertebral arteries where they leave the subclavian arteries. Even though the atlas is at the top of the cervical spine and the above-mentioned structures are near the base of the neck, a subluxation of the atlas and skull can result in these scalenes compressing the brachial plexus and/or the vertebral arteries. This is due to altered weight bearing from a shift in the centre of gravity of the skull, which in causes the muscles of the head and neck to strain in maintaining the head upright on the cervical spine. Also the phrenic nerve, which runs between anterior and middle scalenes on its path to the diaphragm, can be likewise affected by muscle and ligament compression and/or traction.
Atlas-C1 and Axis-C2 Superior viewsubluxation

Figure 1: Upper Cervical Spine - No subluxationFigure 1: Upper Cervical Spine – No subluxation
Figure1 opposite is a drawing of the upper cervical spine articulation between the occiput (C0), the atlas (C1) and the axis (C2). The 'usual' anatomy is for the occipital condyles (cream) of the skull to sit on the atlas condylar surfaces and for the atlas lateral masses (white) (shown cut away) to articulate with the facet joints of the axis (brown) below it. The odontoid peg or dens of the axis should sit about central to the foramen magnum. This is the front (anterior) view, if you were looking directly at the face of this person. The double condyloid joints are represented in this drawing by the 'gaps' between the occiput and atlas lateral masses.
Figure 2: Upper Cervical Spine - Skull to atlas subluxation Figure 2: Upper Cervical Spine – Skull to atlas subluxation
Figure 2 opposite shows what can happen to the 'usual' anatomy in Figure 1, when a force is applied to the skull on one side. The blue arrow indicates the direction of trauma, which in this case is from the left side of the person's head. This trauma can take many forms. In my case it was my head striking the ground in a football tackle. For one little girl it was falling out of bed and hitting her head on the bedside table and for another lady playing basketball, it was a direct hit to the jaw. The force is enough to push the skull sideways as it slides along the atlas condylar surface. The occipital condyles of the skull can slide off (over or underlap) the atlas condylar surface, however the anatomy and the restraining ligaments limit this over and underlapping. The result in this example is a head tilted to the left, and an atlas that's high (elevated) on the right. The axis dens is no longer central to the foramen magnum. See then animation OCCIPUT TO ALTAS SUBLUXATION to view the mechanism of injury. The actual slope of the atlas condyles will determine whether or not the atlas will actually rotate a little with respect to the occiput (skull) and to the axis (C2). Flatter condyles will result in slight rotation of the atlas, whereas steep angled condyles will most likely not produce a great deal of rotation. The skull is quite heavy thus any change in the centre of gravity will most likely produce undesirable stresses on structures within the tissues of the cervical spine. This situation has important implications for the spinal cord, which leaves the foramen magnum and travels through the foramen (holes) in the atlas and other skeletal vertebrae to the base of the spine. This also has important implications for the vertebral arteries, which travel through the cervical spine from C6 to the atlas, for the carotid arteries, which travel beneath the sternocleidomastoid muscles, and for the cranial nerves leaving foramen in the skull base. All of these structures have the potential to be trapped, compressed, stretched or otherwise interfered with by the taught muscles and ligaments involved in maintaining the skull and its contents on top of the cervical spine. The resultant stresses on arteries could yield reduction in oxygenated blood flow to the brain, and on cranial nerves could result in attenuation of nervous system signals to and from the brain. The cranial nerves which are potentially involved are the vagus, spinal accessory, glossopharyngeal and hypoglossal. Of course these arteries and nerves are of major importance to proper functioning and maintenance of the human body.
Figure 3: Even Death does not hide the proof! Figure 3: Even Death does not hide the proof!
(Source: The Chiropractic Story silently told in a medical museum – William G. Blair D.C., Ph. C., F.I.C.A., ©1973)
Copyright permission granted by Mrs Blair and Dr. E. Addington, Blair Chiropractic Clinic, Lubbock, Texas, USA.
Website: http://www.blairchiropractic.com
Figure 3 opposite is the skeleton of a soldier from the Spanish American War (1898). He developed chronic rheumatoid arthritis, the disease progressing and fusing most of his joints from his skull to his sacrum. His teeth had to be removed in order to feed him since the rheumatoid arthritis had also fused his jaw. Following his death and in accordance with his will his body was given to the Army Medical Museum. His family honoured his request and the skeleton is today displayed in the museum. Dr. William G. Blair was given permission to examine and photograph the skeleton. Figure 3, shows the head inclination as a result of a subluxation in the upper cervical spine. Since rheumatoid arthritis does not progress in death it is demonstrably obvious that the "spinal joints are fixed in the same position they occupied at the time of fusion occurred" and "since fusion can take place only in a living person, the present position of these spinal vertebra in death are the same as they were during life". These images are powerful and help to prove the existence of such subluxations of the upper cervical spine, which are the focus of specific upper cervical chiropractors like Dr. Blair and of my website. I suggest that it would be interesting indeed to hypothesise that rheumatoid arthritis is one sequelae of subluxations like this of the upper cervical spine. Fusing of joints may well be the body's way of protecting the spinal cord, brainstem and surrounding neurological and vascular structures from damage, by allowing no additional movement, which would compromise them further. Certainly it would not be the only disease process, which would be initiated if someone sustained such a condition! This injury is so high up and so close to the human central processing unit and other structures, as mentioned earlier, that it's not hard to visualise such subluxations may well be a root cause of human illness.
Figure 4: A close look at the subluxation!Figure 4: A close look at the subluxation!
Page 9 of Dr. Blair’s document (The Chiropractic Story silently told in a medical museum – William G. Blair D.C., Ph. C., F.I.C.A., ©1973) shows the photograph in Figure 4 opposite. Let’s have a closer look at the anatomy of this subluxation. The numbered structures are: 1. Right mastoid process; 2. Right styloid process; 3. Right side occipital bone; 4. Right occipital condyle; 5. right lateral mass of the atlas (C1); 6. Right side posterior arch of atlas; 7. Right lamina of axis (C2).
According to Blair, "You will note the fusion of all three cervical vertebrae. These vertebra are fused not only at the usual joints but also at an unusual union of the posterior arch of first cervical (6) with the right lamina of the second cervical (7). Since the growing together process can take place only in the living body, every structure is fused in the exact position it occupied during life.
Continuing our examination of Figure 4, note the two arrows. The arrow on the left points to the outside (distal) margin of the right occipital condyle (4). The arrow on the right points to the outside (distal) margin of the right lateral mass of the first cervical vertebra (5). These are the margins of the adjoining joint surfaces. Without misalignment the two arrows would line up, instead there is displacement. The first cervical vertebra is decidedly misaligned with the skull. By actual measurement on the skeleton this displacement amounts to 3/8 of an inch (approx. 1cm). The second and third cervical vertebrae have followed the first cervical vertebra to the misaligned position."
Figure 5: An even closer look at the subluxation!Figure 5: An even closer look at the subluxation!
Page 10 of Dr. Blair's document shows these numbered structures: 1. Right mastoid process; 2. Right styloid process; 4. Right occipital condyle; 5. right lateral mass of the atlas (C1); 6. Right side posterior arch of atlas; 9. Right jaw (ramus of mandible). According to Dr. Blair, "Note the two arrows. The arrow on the left points to the front (anterior) margin of the right occipital condyle. The arrow on the right points to the front (anterior) margin of the right lateral mass of the first cervical vertebra. Again these margins are of adjoining joint surfaces. If there were no misalignment, the two arrows would line up. Again there is displacement. Again the first cervical vertebra is decidedly misaligned with the skull. The actual amount of misalignment on the skeleton is 5/8 inch (approx. 1.6cm). Also note the bony fusion of first cervical lateral mass, number 5, to the body of the second cervical vertebra below and to the occipital condyle above, number 4. These structures having grown together during life are found in exactly the same position after death as they were during life. The body of the second cervical vertebra has followed the atlas to the misaligned position and is aligned (juxtaposition) with the atlas."

Figure 6: The Effects of the Atlas SubluxationFigure 6: The Effects of the Atlas Subluxation
(Figure 6 - reprinted with permission from Daniel O. Clark D.C., Website: www.uppercervicalillustrations.com).
Figure 6 opposite provides information about the effect an atlas subluxation will have on the surrounding ligaments and muscles. In this case the head is tilted to the right, the chin will be rotated to the left and the neck will be in a left inflexion. The ligaments and muscles in the sub-occipital area and those holding the head on to the cervical spine will now be under stress and/or go into spasm. The spinal cord (brainstem just above C1) will be 'kinked' at the craniocervical junction (skull to atlas articulation). See the animation KINK SUBLUXATION to view the mechanism of injury. The average human skull and its contents weigh in at around 4.5 to 6 kg (approx. 10 to 14 pounds), and under normal circumstances one can bend and rotate their neck without compromising the critical neurological structures at this level. However, when this 4.5kg (10 pounds) 'bowling ball' is shifted the whole centre of gravity throughout the cervical spine changes and this altered weight bearing will have negative effects on neurological and vascular structures at the base of the skull and throughout the neck, especially those structures which are in close proximity to the muscles under stress. Remember that the vertebral arteries and 1st cervical nerves pierce the posterior occipito-atlantal ligament and it is highly possible that this and other ligaments will irritate both these structures. The sub-occipital and cervical ligaments and muscles implicated in this situation include but are not limited to the rectus capitus posterior minor and major, obliquus capitis superior, obliquus capitis inferior, sternocleidomastoid, leveator scapula, trapezius and scalenes (in particular the anterior scalenes). Go to a bowling alley and pick up a 10-pound bowling ball. Balance the ball on your fingers and then tilt your hand so that the centre of gravity is now altered. You will soon find out how hard it is to maintain this position for very long. I know that in my own circumstance, my trapezius muscles were so painful that I found it relieving to allow my head posture to go forward, although over time the only relief was through putting my head down on a surface or laying down in a bed. The stressed muscles and those in spasm will begin to waste and over time this is very noticeable in sick people. Their posture can be used as window into their health. There is so much atrophy in the neck and shoulder muscles of people with obvious atlas subluxations that part of the healing process or approach, after the correction of the atlas subluxation, must include rehabilitation of these muscles. This atrophy is very noticeable in people suffering from Parkinson's disease, Multiple Sclerosis and other neurological diseases. For further information on a suggested rehabilitation process for sufferers of an atlas subluxation see my section "A NEW APPROACH TO WELLNESS"
Figure 7: The Effects of the Atlas SubluxationFigure 7: The Effects of the Atlas Subluxation
(Figure 7 reprinted with permission from Daniel O. Clark D.C., Website: www.uppercervicalillustrations.com).
Figure 7 opposite explains what happens to your body if you unfortunate enough to sustain a head injury which shifts your skull on your atlas and results in a skull to atlas subluxation. Make no mistake for this is exactly what happens. The ramifications of the subluxation can extend to all parts of your body. In the most benign of these subluxations you may only experience a little lower back pain and in the more serious your whole body can be racked with pain and dysfunction. The tight sub-occipital ligaments and cervical spine muscles can be responsible for headaches or migraines as well as neck pain.
Figure 8: Myodural Bridge
Some years back Gary Hack D.D.S. et al 1995. "Anatomic relation between the rectus capitus posterior minor and the dura mater" Spine 20 (23): 2484-2486 discovers a previously unknown ligament directly attaching the posterior arch of the atlas to the dura mater of the brainstem and cerebellum. This attachment has become known as the myodural bridge and it is shown following in Figure 8.
The structures numbered in this dissection are as follows; 1. Posterior arch of the atlas; 2. Posterior occipital bone; 3. Rectus capitus posterior minor (RCPMI); 4; Dura mater of brainstem and cerebellum. The arrows indicate the myodural bridge attaching the posterior arch of the atlas to the dura mater of the brainstem & cerebellum. It is not difficult to see that any misalignment of the atlas with respect to the skull could traction the dura mater of the brainstem and cerebellum area. What would be the effects of such traction? Certainly it is possible for headaches and migraines to be an effect, but also there may well be other consequences. Researchers at Michigan State University; "College of Osteopathic Medicine" suggest "that the function of the RCPMI muscle is to provide static and dynamic proprioceptive feedback to the CNS (central nervous system), monitoring movement of the head and influencing movement of the surrounding musculature." In fact amongst other joints, the joints of the upper cervical spine are rich in proprioceptors, which provide positional feedback to the brain, in order for the brain to understand where the joints and therefore the head are in space and to make appropriate adjustments during movement. Close your eyes and point your first fingers on both hands. Now try and touch the tips of these fingers without opening your eyes. Your ability to touch your fingertips is an indication of your proprio receptive abilities. Any problems in this area may well be responsible for over and under corrections made by your brain, which would manifest as dizziness or balance disorders. Atlas subluxations, especially because they go hand in hand with some atrophy of these sub-occipital cervical muscles, could manifest as dizziness and/or balance disorders. Meniere's Disease has been associated with cervical dysfunction in a number of medical papers, and I have personally witnessed and know of other people diagnosed with Meniere's Disease who have had dramatic reversal of the disease's symptoms following upper cervical correction to their atlas vertebra by specific upper cervical chiropractors. This deserves further investigation as Meniere's Disease and other balance disorders are highly distressing to sufferers.
Now looking at Figure 7 further you will note that because the skull is tilted the pelvis will pull up on one side to compensate for the body imbalance and pull that leg off the ground. This is known as a functional short leg as opposed to an anatomical short leg. Of course, the leg is not off the ground because the weight of the body keeps it on the ground during walking. With the pelvis pulling up on one side the spinal column will now twist into scoliosis. Now the back muscles are contracting on one side which creates trigger points mainly at the 's' bend points in the scoliosis, lower back pain is evident and now hip problems can be a result. Leave this for long enough and the result may be surgical replacement of a degenerated hip. Knee, ankle, groin and calf problems can be a direct result, which people normally pass off as an aging thing or an accident. For me this explains the back pain all the way down my back and my ankle and knee problems, which corrected following correction of my atlas subluxation. The brain is the key initiator of this lifting of the pelvis, in order to align the pelvis and skeleton underneath the skull. There are cases of scoliosis that have resolved completely or at least improved considerably following upper cervical specific chiropractic correction of an atlas subluxation. Re-position the skull on top of the atlas, and thus cervical spine and the pelvis will be realigned directly underneath the skull.
Figures 9 & 10: NUCCA Types
Figures 9 & 10 reprinted with permission of National Upper Cervical Chiropractic Association - see Website www.nucca.org with special thanks to Robert Goodman, D.C. NUCCA

Figure 9

Figure 10
These graphics from the NUCCA site also show further the types of subluxations that can occur at the upper cervical spine level.
Which one actually occurs in each individual really depends upon their prevailing anatomy at that level and the direction and amplitude of the force imparted during the trauma they received. While it is not always the case, I have noticed that some people who have particularly large misalignments in their upper cervical spine sometimes can exhibit only minor symptoms, whilst others who have less of a misalignment can be in a very bad state in terms of the symptoms they are experiencing.
UPPER CERVICAL ANIMATIONS
The Sid E. William Research Center at Life University www.life-research.edu [Note: this website is currently unavailable] has some absolutely fantastic cervical spine animations showing different motions and subluxations within the cervical spine. I have chosen a couple of the animations to help explain further the anatomy of the atlas subluxation and what happens to the occipito-atlantal joint when there is a traumatic event. These animations follow herein.
ANIMATION 1: The Kink Subluxation
Animation 1: Copyright permission granted by Life University with special thanks to J. Roger Hinson, D.C.
This is known as the Grostic Kink Subluxation. This animation shows the movement of the skull and atlas with respect to the lower cervical spine. Play Movie
To play the animation RIGHT CLICK the PICTURE and click Linked Video Clip Object and click Play Link or click on the following Hyperlink Kink Subluxation.
Within the Media Player you can use the slider to move the animation slowly through the subluxation. When you do this and leave the slider in a position about halfway along you will now note the position that the skull will be left in following a traumatic force to the skull, which stretches the ligaments strapping the skull to the upper cervical spine.

ANIMATION 2: The Occipito-Atlantal
Animation 2: Copyright permission granted by Life University with special thanks to J. Roger Hinson, D.C.
This animation shows the movement of the skull with respect to the atlas in lateral flexion to opposite sides. The skull slides with respect to the lower cervical spine, and because of the skull weight and ligaments its movement will drive and jam the atlas.Play Movie
To play the animation RIGHT CLICK the PICTURE and click Linked Video Clip Object and click Play Link or click on the following Hyperlink Occiput to Atlas Subluxation.
Within the Media Player you can use the slider to move the animation slowly through the subluxation. When you do this and leave the slider in a position about halfway along you will now note the position that the skull will be left in following a traumatic force to the skull, which stretches the ligaments strapping the skull to the upper cervical spine.
Go to the Life University Research site and run the animations. You will have a better idea, at least visually of what occurs. www.life-research.edu [Note: this website is currently unavailable]
1. Gray, Henry (1977) Gray’s Anatomy

Upright-health. com - Parkinson's Disease

Parkinson's Disease and NPH

History
The discovery of Parkinson's disease (PD) is attributed to James Parkinson in 1817 when he called it shaking palsy. But Parkinson didn't really discover the condition and it didn't just suddenly appear in 1817. The condition actually goes back hundreds if not thousands of years in Traditional Chinese Medicine and Aryuvedic Medicine from India.
discoverer of parkinsons disease
The Chinese character for shaking is wind so Traditional Chinese Medicine doctors referred to Parkinson's disease as a wind condition which is the same as calling it a shaking condition.
The number of people afflicted with Parkinson's disease (PD) in the United States alone is estimated to be somewhere between half a million to a million and a half. Despite decades and billions of dollars in research, however, the numbers are actually increasing. What is more alarming, is that there has been a significant increase in the incidence of early onset Parkinson's.
Parkinson's, Alzheimer's and NPH
PD shares a peculiar relationship with Alzhiemer's disease in that both can progress and develop similar signs and symptoms. Many years ago I discovered that they also share an association with normal pressure hydrocephalus (NPH). There weren't enough brain scans when I started my research, now they are plentiful and the evidence is starting to mount about the connection between chronic cerebrospinal venous insufficiency (CCSVI) and NPH in Parkinson's. Upright brain scans will be the wave of the future.
In addition to the role of CCSVI and NPH in PD, I believe PD is also associated with Chiari malformations. The cause of CCSVI, Chiari malformations and NPH is most likely the result of inherited genetic design problems in the drainage system of the brain. The other most likely cause is due to acquired disorders and degenerative conditions of the cervical spine, especially the upper cervical spine and base of the skull.
Primary Parkinson's Disease
Currently primary PD is attributed to a decrease in dopamine production on the part of the substantia nigra. The reason for the decrease in dopamine production, however, is unknown. Supposedly the substantia nigra just goes bad one day and stops producing the way it should. But what causes such a small and highly localized area of the brainstem to suddenly start to go bad while the rest of the brain, for the most part, is working fine?
substantia nigra in the brain stem The picture in the upper left corner above is a sagittal (side view) of the brain stem with a cross section removed and layed out in the main picture. In this picture the substantia nigra (long grey area on either side of the cross section) is actually part of a system of interconnecting nerve centers, called the basal ganglia, and a router called the thalamus located in the core of the brain and brainstem that fine tunes the coordination of the movement of muscles. The basal ganglia take in and process information from different hard drives in the brain, called lobes, which among others include the motor and premotor cortex of the frontal lobe. The motor cortex sends the commands out for movement and the premotor cortex provides stored programs for that particular movement such as riding a bike or throwing a ball.
dopamine, brain neurotransmitters
For another perspective the picture above is a coronal view (looking at the back of the head and removing a slice in the middle of the brain from top to bottom and from side to side. The first three structures listed are part of the basal ganglia and the substantia nigra and thalamus are also shown.
Memories of motor activities, however, reside in all the lobes of the brain, not just the motor cortex. The brain pictures riding a bike in the occipital lobes, at the rear of the brain, and stores long term memory of things about riding a bike in the temporal lobes, located on either side of the brain next to the ears, such as watch out for potholes and roads are slippery when wet. The parietal lobes, above the top of the ears, integrate and associate the information from smell, sight, sound, taste and touch. Some western athletes and all eastern martial arts use Zen visualization techniques, such as watching videos and mental imaging, to stimulate the occipital lobe to train muscles without using them.
Muscle movement requires fast timing and ultrahigh speed components. Consequently, in contrast to most of the brain, the interconnecting system of the basal ganglia uses a high speed neurotransmitter called acetylcholine.
The grey matter of the brain is for processing and integrating information and uses slower speed neurotranmitters such as dopamine. The substantia nigra also uses dopamine. We are now finding out that there is much more to dopamine than simply muscle movements and tremors. Among other things, it appears to play a role in long term memory.
The role of the substantia nigra and it's neurotransmitter dopamine is to take the rough edges off movement by slowing down and smoothing out muscle activity which prevents overexcitation and tremors.
substantia nigra in brain
Again, the picture above shows the substantia nigra in blue on the brainstem and other structures of the basal ganglia.
The thalamus is the top of the brainstem which is located in the core of the brain and is extremely complex. But one of its primary roles is to serve as a router for distributing information about muscle movement to the different hard drives of the brain. The hypothalamus sits below the thalamus and also appears to play a role in muscle movement.
In contrast to the substantia nigra, which when malfunctioning produces resting tremors as seen in Parkinson's, injuries to the hypothalamus appear to play a role in wild, erratic, exaggerated tremors such as those seen in Huntington's Disease. Interestingly, Huntington's disease is similar to PD in many ways and will be discussed separately on this website.
Secondary Parkinson's Disease
Secondary PD is due to other causes rather than a decrease in dopamine production. It can be due to a decrease in the effect of dopamine on its target nerves. Secondary PD can also be caused by toxins such as, but not limited to, pesticides, excess manganese, alchohol, certain types of blood pressure medicine such as reserpine, psychotropic drugs and recreational drugs.
Secondary PD can also be caused by tumors and infarcts (dead tissue in the brain). It has always been associated with boxing, which used to be called pugilistic PD. For further information on this subject go to Parkinsons, dementia and neck injuries.
Parkinson's and NPH
Decades ago, I suspected that PD was most likely due to venous drainage issues and NPH similar to Alzheimer's. Among other things, CCSVI from back pressure against the venous drainage system of the brain can decrease the cerebrospinal fluid (CSF) pressure gradient and subsequent production of CSF. A decrease in the passive production of CSF would result in a decrease in CSF volume in the brain during upright posture. This could cause the brainstem to sink into the foramen magnum, which is called a pressure conus or Chiari condition.
Pressure conus and Chari conditions, in turn plug venous drainage outlets in the basement of the brain resulting in CCSVI. They also compress CSF pathways, resulting in impaired and sluggish CSF flow and subsequent NPH.
Chiari, NPH and Compression of The Substantia Nigra
The cerebellum and brainstem sit in what is called the posterior fossa (back of the skull). The foramen magnum lies on the floor of the posterior fossa. The brainstem lies parallel to and along the angle of what is called the clivus, which unites the occipital bone of the posterior fossa with the sphenoid bone in the middle fossa above, which is also part of the base of the skull. These structures are shown below in a sagittal view (the skull sliced in half from the front to back.)
bent base of cranium
The posterior fossa is covered by dura mata called the tentorium cerebelli, which means the tent of the cerebellum. In addition to a large portion of the brainstem, the posterior fossa also contains the cerebellum and most of the cranial nerves. The tentorium cerebelli separates the contents of the posterior fossa from the rest of the brain in the anterior and middle fossas above.
The picture below shows a coronal view of posterior brain compartments and the foramen magnum at the base.
compartments of the brain
Chiari conditions result in compression of the brainstem against the rim of the foramen magnum. Flexion type strains of the cervical spine, in which the head is in a position forward of the preferred perpendicular postural gravity line, traction the cord and brainstem toward the front edge of the foramen magnum. Normally, looking at person from the side, the mastoid bone behind the ear should line up over the malleoli (outside bone) of the ankle.
chiari malformation
The picture above is a sagittal view of the lower brain, brainstem, skull and cervical spine. This picture shows the relationship of the brain stem to the foramen magnum which is immediately above the cervical spine.
A Parkinson's patient's posture is stooped due to the areas of the brain impacted on.
man with Parkinson's
The substantia nigra is located in the pons area on the belly side of the brainstem making it equally susceptible to compression, Interesingly, the periaqueductal grey also lies nearby and plays a role in the freeze reflex, which could explain the frozen facial expressions and cogwheel rigidity-type movement seen in PD.
It is my opinion that CCSVI causes NPH and Chiari type conditions resulting in compression of the area of the brainstem that contains the substantia nigra. Furthermore, CSF entrapment from NPH can also cause increased pressure in the fourth ventricle which compresses important structures in the cerebellum such as the flocculonodular lobe.
The flocculonodular lobe is one of oldest parts of the brain in vertebrate evolution. Among other things, it controls truncal muscles related to posture, movement and balance and may play a role in stooped posture, rigidity of truncal muscles, problems with walking and loss of balance.
A variant of Parkinson's disease of multisystem atrophy and is covered on a separate page.

Wednesday, 4 December 2013

Motor Neuron disease, is it not all atlas related

What are the symptoms of motor neuron diseases?


A brief description of the symptoms of some of the more common MNDs follows.
Amyotrophic lateral sclerosis (ALS), also called Lou Gehrig's disease or classical motor neuron disease, is a progressive, ultimately fatal disorder that disrupts signals to all voluntary muscles.  Many doctors use the terms motor neuron disease and ALS interchangeably.  Both upper and lower motor neurons are affected.  Symptoms are usually noticed first in the arms and hands, legs, or swallowing muscles.  Approximately 75 percent of people with classic ALS will develop weakness and wasting of the bulbar muscles (muscles that control speech, swallowing, and chewing).  Muscle weakness and atrophy occur on both sides of the body.  Affected individuals lose strength and the ability to move their arms and legs, and to hold the body upright.  Other symptoms include spasticity, spasms, muscle cramps, and fasciculations.  Speech can become slurred or nasal.  When muscles of the diaphragm and chest wall fail to function properly, individuals lose the ability to breathe without mechanical support.  Although the disease does not usually impair a person's mind or personality, several recent studies suggest that some people with ALS may develop cognitive problems involving word fluency, decision-making, and memory.  Most individuals with ALS die from respiratory failure, usually within 3 to 5 years from the onset of symptoms.  However, about 10 percent of affected individuals survive for 10 or more years.

I imagine ALL are Atlas related, I've had some esp walking on rocks,

Paresthesias - Things That Go B...

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PARESTHESIAS


Yesterday upon the stair
I met the man that wasn't there.
He wasn't there again today.
Oh, I wish he'd go away!




Paresthesias are among the most common problems in MS.  A paresthesia is simply an abnormal sensation without an apparent cause.  But, understanding what they really are as applied to ourselves are can be a little tricky.  To really understand what can be happening, one needs a basic understanding of what a nerve is doing.


A Little Bit About Nerves and How They Work

Nerves can carry a signal in only "one" direction.  Ever.  All nerves are this way.  The main nerves that we deal with in MS are the motor nerves and the sensory nerves.  The motor nerves carry the signal "from" the brain to the muscles.  We want to move and the brain sends the signals to cause the muscle to contract.  The sensory nerves carry signals of sensation or feeling in the opposite direction, from out in our body "to" our brain.  This is how we experience the world.

Sensory nerves come in many flavors depending on the type of nerve ending.  There are special nerve endings for pain, soft touch, pressure, heat, vibration and many othersincluding the special senses of sight, smell, hearing, and taste.  When a sensory nerve ending is stimulated the nerve carries the information to the brain and we percieve or feel it.  If a pain nerve is stimulated by injury, whether by a thorn or a broken bone, we feel pain.  The difference in how much pain we feel depends on how many nerves are stimulated and how fast they fire.  The faster they fire the more painful something is.

Not Enough Signal

When a nerve is damaged it can do several things. The effect can be Negative.  It can have no signal arrive at all or the signal may be reduced in strength. If it is totally interrupted on it's way to the brain no signal at all will get through. This causes numbness. Even if the interruption is high up in the spinal cord or the brain, if it doesn't arrive at its destination in the final area of the brain there is no sensation from it.  So, if the foot is injured, there may be a normal pain signal in the nerve almost all the way up, but if it is completely interrupted before reaching the final spot in the brain, there is no pain felt.  The area is numb.  Numbness is the final result when any of the sensory nerves are completely cut off.  So when an area is really totally numb we can't feel touch, pain, hot, cold - anything.  

Also, a damaged nerve may have a reduced signal arriving at the brain.  In this case we will feel pretty much the correct sensation, but not enough of it. This is also a negative (reduced) effect.  If the nerves carrying the sensation of heat are affected by MS, then we may think that very hot bath water is just warm and we may burn ourselves.  The sensation of warmth is not an abnormal sensation, it is just not enough of the normal sensation.  This is not technically a paresthesia.



PARESTHESIAS - Too Much Or the Wrong Kind of Signal


The opposite of a Negative signal is a Positive error signal.  The signal is there, but it is too much or it brings wrong information.  It may also bring information when there is no reason for it to be carrying a signal, like the tingling hand that isn't being touched or tickled.   These positive error signals are called "paresthesias."

When a sensory nerve is damaged, like in MS, if it can send a bad signal to the brain.  We feel this as a paresthesia.  It sends signals that are inappropriate to what is happening.  Our feet or face may tingle, but there is nothing causing the tingling.  We may feel a band-like sensation around our chest or around a limb. but there is nothing wrapping around us to cause it.  The tongue might feel burned, but there have been no hot foods.  When we flex our neck, a lightening sensation may zap in various areas (L'Hermitte's), but no one is behind us with a cattle prod.  A common problem is the sensation of a hot or cold patch (which we sometimes interpret as wet).  Many people have experienced itching in an area that is numb after surgery.  Scratching the itchy, but numb, area is useless and does not relieve the itch.

A paresthesia may be constant or it may be intermittent.  It can also be triggered when something does stimulate the area, as when simple soft touch is felt as unbareably painful.  This is a condition of paresthesia known as allodynia.

The special senses of sight, smell, hearing and taste may also be affected in MS and cause paresthesias.  In Optic Neuritis, a person may see flashing lights, halos, wavy lines, things that appear to scurry round in the peripheal vision.  These are paresthesias.  If the visual signal is reduced there my be shadows, visual field defects, or diminished color saturation (intensity).  The sense of smell may disappear.  Or we may have paresthesias of smells that are not there.  For some reason these smells are always odd and usually very unpleasant.  (why can't we smell cinnamon or lilacs?).  Loss of hearing is also not uncommon in MS.  Paresthesias of hearing and taste occur, but are less common.


The Special Case of Pain

In truth, pain can be a paresthesia.  If there is no injury to the body part, but it hurts anyway, it is a painful paresthesia.  However, pain is just usually called "pain."   In medicine we tend to call it nerve pain or neuropathic pain.  Just like other paresthesias it can be constant or intermittent.  It can be stimulated by touching the painful part or it can also occur spontaneously (all by itself).  People tend to think all paresthesias have to do with the skin, but pain especially can occur in any area that has sensation, including deep in the muscles or bones in the abdomen, the throat or anywhere else that has sensation.  

Other Examples of Paresthesias
  • Burning without cause
  • Itching without reason
  • A feeling of a vibration or a buzzing or an electrical feeling.  I have heard it described in every part of the body, from within the head, down the spine, on the torso or a limb.  Many describe it like feeling that they have a cell phone on silent "vibrate" in that area.
  • Feeling like one is walking on rocks, but the ground is smooth.
  • The sensation that there is a rock in the shoe.
  • Feeling like the fingers or toes are crossed.
  • Feeling like there are insects or something crawling on you.
  • Feeling like there is urine running down your leg or warm liquid on you someplace else.
  • Seeing a small dark object scurring through the corner of your sight (the mouse in the house phenomenon)
Paresthesias are not harmless.  Though the sensations themselves do no harm, their very presence can destroy the quality of life.  Many just cannot be ignored.  They also can cause secondary problems by giving us bad information about our world.  We can be burned or injured if we don't feel/perceive the threatening object.  Visual paresthesias may obscure something we need to see to get around effectively or to drive.  We may drop something because we didn't have good information about whether we have it securely. The hand holding it was tingling, but not sending touch and pressure information correctly to the brain.

On the other hand, we can become so accustomed to having paresthesias that we ignore real sensations.  This can be just plain embarassing when we ignore the syrup on our chin or harmful when there really is a rock in the shoe.

Paresthesias that are affecting the quality of life can be treated, much like nerve pain is treated.   See the Health Page listed under TREATMENTS --> Pain for a discussion of this.

Quixotic1

Tuesday, 3 December 2013

pediat cancer patient and Candida-old info but may be relevant

Semin Oncol. 1990 Jun;17(3 Suppl 6):6-9.

Fungal infections in the pediatric cancer patient.

Source

Infectious Disease Section, National Cancer Institute, Uniformed Services University of the Health Sciences, Bethesda, MD 20892.

Abstract

Chemotherapy, while undeniably effective in controlling or eradicating a variety of neoplasms, is also accompanied by a number of toxicities. Foremost among these is neutropenia, which places the pediatric cancer patient at risk for serious fungal infections. The fungal organisms most commonly responsible for infection in neutropenic children are Candida, Aspergillus, Mucor, and the Phycomycetes. Common sites of infection include the oral cavity, sinuses, lung, and bloodstream. Recently, candidal infection of the liver was recognized as a growing problem. Diagnosis of deep-seated fungal infections, such as pneumonia and hepatic candidiasis, is extremely difficult, often requiring open-lung or liver biopsy, which a patient's hematologic status may not permit. Because early treatment significantly improves prognosis, empirical antifungal therapy may be indicated in selected patients. Amphotericin B is currently the antifungal agent of choice against most fungal organisms. Antifungal efficacy studies based on animal models of disseminated candidal infection suggest that amphotericin B combined with 5-fluorocytosine (5-FC) is more effective than amphotericin B alone against most deep-seated Candida infections. The investigational drug, fluconazole, appears as effective as amphotericin B plus 5-FC in the prevention and early treatment of disseminated candidiasis, and clinical trials to assess this potentially important role for the new antifungal agent are now being initiated.
PMID:
2191445
[PubMed - indexed for MEDLINE]

Publication Types, MeSH Te

side effects of antibiotics - is this not a warning

Side effects of antibiotics  

Tetracyclines and sensitivity to light 

Tetracyclines can make your skin sensitive to sunlight as well as artificial sources of light such as sun lamps and sunbeds.
You should avoid prolonged exposure to bright light while taking tetracyclines.
The most common side effects of antibiotics affect the digestive system. These occur in around 1 in 10 people.
Side effects of antibiotics that affect the digestive system include:
  • being sick
  • feeling sick
  • diarrhoea 
  • bloating and indigestion
  • abdominal pain
  • loss of appetite
These side effects are usually mild and should pass once you finish your course of treatment.
If you experience any additional side effects other than those listed above you should contact your GP or the doctor in charge of your care for advice.