Saturday, 29 October 2016

MDR - Multiple drug resistance - Repost 2014***************

Multiple drug resistance (MDR), multi-drug resistance or multiresistance is a condition enabling disease-causing microrganisms (bacteria, viruses, fungi or parasites) to resist distinct antimicrobials, first and foremost antibiotics,but also antifungal drugs, antiviral medications, antiparasitic drugs, chemicals of a wide variety[1] of structure and function targeted at eradicating the organism. Recognizing different degrees of MDR, the terms extensively-drug resistant (XDR) and pandrug-resistant (PDR) have been introduced. The definitions were published in 2011 in a journal called "Clinical Microbiology and Infection" and are openly accessible[2] This article discusses multi-drug resistance of bacteria, fungi, viruses and parasites, not that of tumor cells, which are discussed in the section of antineoplastic resistance.
Table of Contents
1Common multi-drug-resistant organisms (MDROs)
2Bacterial resistance to antibiotics
3Antifungal resistance
4Antiviral resistance
5Antiparasitic resistance
6Preventing the emergence of antimicrobial resistance
7See also
9Further reading
10External links

Common multi-drug-resistant organisms (MDROs) [edit]

are usually bacteria:
A group of gram positive and gram negative bacteria of particular recent importance have been dubbed as the ESKAPE group (Enterococcus faecium,Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumanii, Pseudomonas aeruginosa)[3]

Bacterial resistance to antibiotics [edit]

Various microorganisms have survived for thousands of years by their ability to adapt to antimicrobial agents. They do so via spontaneous mutation or by DNA transfer. This process enables some bacteria to oppose the action of certain antibiotics, rendering the antibiotics ineffective.[4] These microorganisms employ several mechanisms in attaining multi-drug resistance:
Many different bacteria now exhibit multi-drug resistance, including staphylococci, enterococci, gonococci, streptococci, salmonella, as well as numerous other gram negative bacteria and Mycobacterium tuberculosis. Some resistant bacteria are able to transfer copies of DNA that code for a mechanism of resistance to other nearby species of bacteria, thereby conferring resistance to their neighbors, which then are also able to pass on the resistant gene. This process is called horizontal gene transfer.

Antifungal resistance [edit]

Yeasts such as Candida species can become resistant under long term treatment with azole preparations, requiring treatment with a different drug class. Scedosporium prolificans infections are almost uniformly fatal because of their resistance to multiple antifungal agents.[7]

Antiviral resistance [edit]

HIV is the prime example of MDR against antivirals, as it mutates rapidly under monotherapy. Influenza virus has become increasingly MDR; first to amantadenes, then to neuraminidase inhibitors such as oseltamivir, (2008-2009: 98.5% of Influenza A tested resistant), also more commonly in immunoincompetent people Cytomegalovirus can become resistant to ganciclovir and foscarnet under treatment, especially in immunosuppressed patients. Herpes simplex virus rarely becomes resistant to acyclovir preparations, mostly in the form of cross-resistance to famciclovir and valacyclovir, usually in immunosuppressed patients.

Antiparasitic resistance [edit]

The prime example for MDR against antiparasitic drugs is malaria. Plasmodium vivax has become chloroquine and sulfadoxine-pyrimethamine resistant a few decades ago, and as of 2012 artemisinin-resistant Plasmodium falciparum has emerged in western Cambodia and western Thailand. Toxoplasma gondii can also become resistant to artemisinin, as well as atovaquone and sulfadiazine, but is not usually MDR[8] Antihelminthic resistance is mainly reported in the veterinary literature, for example in connection with the practice of livestock drenching[9] and has been recent focus of FDA regulation.

Preventing the emergence of antimicrobial resistance [edit]

To limit the development of antimicrobial resistance, it has been suggested to:
  • Use the appropriate antimicrobial for an infection; e.g. no antibiotics for viral infections
  • Identify the causative organism whenever possible
  • Select an antimicrobial which targets the specific organism, rather than relying on a broad-spectrum antimicrobial
  • Complete an appropriate duration of antimicrobial treatment (not too short and not too long)
  • Use the correct dose for eradication; subtherapeutic dosing is associated with resistance, as demonstrated in food animals.
The medical community relies on education of its prescribers, and self-regulation in the form of appeals to voluntary antimicrobial stewardship, which at hospitals may take the form of an antimicrobial stewardship program. It has been argued that depending on the cultural context government can aid in educating the public on the importance of restrictive use of antibiotics for human clinical use, but unlike narcotics, there is no regulation of its use anywhere in the world at this time. Antibiotic use has been restricted or regulated for treating animals raised for human consumption with success, in Denmark for example.
Infection prevention is the most efficient strategy of prevention of an infection with a MDR organism within a hospital, because there are few alternatives to antibiotics in the case of an extensively resistant or panresistant infection; if an infection is localized, removal or excision can be attempted (with MDR-TB the lung for example), but in the case of a systemic infection only generic measures like boosting the immune system with immunoglobulins may be possible. The use of bacteriophages (viruses which kill bacteria) has no clinical application at the present time.

See also [edit]

References [edit]

  1. ^ Drug Resistance, Multiple at the US National Library of Medicine Medical Subject Headings (MeSH)
  2. ^
  3. ^ Boucher, HW, Talbot GH, Bradley JS, Edwards JE, Gilvert D, Rice LB, Schedul M., Spellberg B., Bartlett J. Bad buds, no drugs: no ESKAPE! An update from the Infectious Diseases Society of America. Clincial Infectious Disease (2009); 48: 1-12.
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  8. ^ Doliwa C, Escotte-Binet S, Aubert D, Velard F, Schmid A, Geers R, Villena I. Induction of sulfadiazine resistance in vitro in Toxoplasma gondii.Exp Parasitol. 2013 Feb;133(2):131-6.
  9. ^ Laurenson YC, Bishop SC, Forbes AB, Kyriazakis I.Modelling the short- and long-term impacts of drenching frequency and targeted selective treatment on the performance of grazing lambs and the emergence of antihelmintic resistance.Parasitology. 2013 Feb 1:1-12.

Further reading [edit]

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External links [edit]

APUA or Alliance for the Prudent Use of Antibiotics

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